Department of Radiology

Nanoimaging and Theranostic Laboratory-Department of Radiology
University of Texas Health Science Center at San Antonio


Overview of Theranostic Lab

The Nanoimaging and Theranostic Lab is located in the Department of Radiology at the University of Texas Health Science Center San Antonio.  Faculty members of this lab are Dr. Beth Goins and Dr. William Phillips who have been performing nanoparticle imaging research for more than 20 years.    Dr. Beth Goins is a PhD Scientist with expertise in liposome and other types of nanoparticles as well as non-invasive  preclinical imaging research.  In addition to research, Dr. Goins also teaches courses in the Radiological Science Graduate Program and is currently serving as Associate Director.      Dr. Phillips is a Nuclear Medicine Physician with an active clinical Nuclear Medicine practice as well as  research. In the field of nanomedicine, he has published over 100 scientific articles in peer- reviewed journals.   His research interests have focused on the use of scintigraphic imaging with SPECT and PET agents to monitor and quantitate drug delivery by nanoparticles.   Dr. Phillips has developed new image-based methodologies in the field of Nanomedicine including new methods of tracking nanoparticles with diagnostic radioisotopes and using nanoparticles as carriers for anti-cancer therapeutic radionuclides.  He has used nuclear imaging to facilitate development of improved liposome formulations with in vivo targeting advantages based on their nano-size properties.

Nanotheranostic Lab Capabilities - Available for Collaboration and Contract Research

•Development of stable methods of radiolabeling nanoparticles with imaging tracers
•Performance of quantitative imaging studies to determine the in vivo biodistribution of nanoparticles using non-invasive imaging
•Development of theranostic systems for both imaging and therapy

 

Equipment

•SPECT/PET/CT small animal imaging camera
•Clinical size planar gamma camera.
•Automated gamma counters
•All facilities for the manufacture of liposomal nanoparticles
•Facilities for radiolabeling a variety of nanoparticles

Small Animal PET/SPECT/CT

MRI and Optical imaging are also possible methods of tracking agents in small animals

micro CT/SPECT

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 



Book Published on Nanoimaging by  Dr. Beth Goins and Dr. William Phillips

Nanoimaging Published Book

 

 

 

 

 

 

 

 

 

 

 

 

 

Former Members of Theranostic Nanoparticle Lab Include:

Faculty Members
•Dr. Ande Bao,  Currently at the Case Western Reserve University Hospital in the Department of Radiation Oncology
•Dr. Vibhu Awasthi, now at the School of Pharmacy at the University of Oklahoma Health Science Center.
•Dr. Zheng Jim Wang, now at Oncotherix; adjunct position at Van Andel Institute, Grand Rapids, Michigan
•Graduate Students from the laboratory receiving PhDs perform Nanoimaging Research 
•Dr. Luis Medina,   Universidad Nacional Autonoma de Mexico
•Dr. Anu Soundararajan,   University of Texas Health Science Center at San Antonio
•Dr.  Cristina Zavaleta, Stanford University
•Dr. Yi-Hsiu (Stella) Chung, Chang Gung University, Taiwan

External Collaborators

•Dr. Keitaro Sou, Polymer Chemist
•Dr. George Negrete, Chemist
•Dr. Andrew Brenner, Medical Oncologist
•Dr. Alan Rudolph, Blood Substitute Researcher
•Dr. Huan Xie, Pharmaceutical Scientist

 

Research Interests

•Nanoparticle Drug Delivery with imaging
•Theranostic nanoparticles delivered directly into tumors using CED.
•Lymph node targeted nanoparticles for vaccines
•Bone marrow targeted nanoparticles
•Intraperitoneal delivery of theranostic nanoparticles
•Theranostic nanoparticles for infection and inflammatory disease applications

 

Publications and Examples from the Theranostic Lab

More than 105 peer reviewed articles and greater than 25 book chapters - including a book entitled “Nanoimaging”


Direct 99m-Tc Labeling of Pegylated Liposomal Doxorubicin
Effect of Intratumoral Administration on Biodistribution of 64Cu-Labeled Nanoshells
Novel Method of Greatly Enhanced Delivery of Liposomes to Lymph Nodes
Rhenium-186 Liposomes